... beta sheets form the PIP2 binding site [31]. ... binding of Ca2+ and enhanced hydrolysis of PIP2 [189]. ... Essen LO, et al., A ternary metal binding site in ...
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Abstract. Phospholipase C beta2 (PLC beta2) is activated by G protein betagamma subunits and calcium. The enzyme is soluble and its substrate, ...
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This enzyme is extremely resistant to degradation even though it does not have disulfide bridges. Zn2 + apparently maintains the structure of the enzyme rather ...
PLCB2, PLC-beta-2, phospholipase C beta 2. External IDs, OMIM ... metal ion binding · phosphatidylinositol ... lipid metabolism · Wnt signaling pathway, calcium ...
#Lipid degradation · #Lipid metabolism. Ligand. #Calcium · #Metal-binding. Enzyme ... Phosphoinositide phospholipase C-beta-2; Phospholipase C-beta-2 (PLC-beta-2) ...
Apr 5, 2024 · These results reveal a complex interplay in which membrane interaction, not just SspB-iLID binding, drives opto-PLCβ activation. Light-dependent ...
These areas could be repelled by the negatively charged membrane upon binding of the PLC to membrane lipids. ... PIP2 ... "The metal ion dependence of phospholipase ...
Parsing the players: 2-arachidonoylglycerol synthesis and degradation in the CNS. Br. J. Pharmacol. 2014, 171, 1379–1391. [Google Scholar] [CrossRef]; Tong ...
#Metal-binding automatic annotation. Enzyme and ... PIRSF000956 PLC-beta 2 hits. PRINTS · PR00390 ... SSF49562 C2 domain (Calcium/lipid-binding domain, CaLB) 1 hit ...
Oct 18, 2019 · HDX-MS reveals conformational changes in the C-terminus and PLCβ core that occur upon membrane binding. Coincubation of PLCβ2 with PS/PE/PIP2 ...